Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).
Identifieur interne : 003709 ( Main/Exploration ); précédent : 003708; suivant : 003710Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).
Auteurs : Ana M. Lopes [France] ; Lorenzo Capucci [Italie] ; Dolores Gavier-Widén [Suède] ; Ghislaine Le Gall-Reculé [France] ; Emiliana Brocchi [Italie] ; Ilaria Barbieri [Italie] ; Agnès Quéméner [France] ; Jacques Le Pendu [France] ; Jemma L. Geoghegan [Australie] ; Edward C. Holmes [Australie] ; Pedro J. Esteves [Portugal] ; Joana Abrantes [Portugal]Source :
- Virology [ 1096-0341 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux, Anticorps monoclonaux, Antigènes viraux (génétique), Antigènes viraux (métabolisme), Conformation des protéines, Facteurs temps, Foie (virologie), Infections à Bunyaviridae (médecine vétérinaire), Infections à Bunyaviridae (virologie), Infections à Bunyaviridae (épidémiologie), Lagovirus (génétique), Lepus (virologie), Modèles moléculaires, Phylogénie, Régulation de l'expression des gènes viraux (physiologie), Suède (épidémiologie), Variation génétique, Épitopes (génétique), Évolution moléculaire.
- MESH :
- génétique : Antigènes viraux, Lagovirus, Épitopes.
- médecine vétérinaire : Infections à Bunyaviridae.
- métabolisme : Antigènes viraux.
- physiologie : Régulation de l'expression des gènes viraux.
- virologie : Foie, Infections à Bunyaviridae, Lepus.
- épidémiologie : Infections à Bunyaviridae, Suède.
- Animaux, Anticorps antiviraux, Anticorps monoclonaux, Conformation des protéines, Facteurs temps, Modèles moléculaires, Phylogénie, Variation génétique, Évolution moléculaire.
- Wicri :
- geographic : Suède.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral (genetics), Antigens, Viral (metabolism), Bunyaviridae Infections (epidemiology), Bunyaviridae Infections (veterinary), Bunyaviridae Infections (virology), Epitopes (genetics), Evolution, Molecular, Gene Expression Regulation, Viral (physiology), Genetic Variation, Hares (virology), Lagovirus (genetics), Liver (virology), Models, Molecular, Phylogeny, Protein Conformation, Sweden (epidemiology), Time Factors.
- MESH :
- chemical , genetics : Antigens, Viral, Epitopes.
- chemical , metabolism : Antigens, Viral.
- chemical : Antibodies, Monoclonal, Antibodies, Viral.
- geographic , epidemiology : Sweden.
- epidemiology : Bunyaviridae Infections.
- genetics : Lagovirus.
- physiology : Gene Expression Regulation, Viral.
- veterinary : Bunyaviridae Infections.
- virology : Bunyaviridae Infections, Hares, Liver.
- Animals, Evolution, Molecular, Genetic Variation, Models, Molecular, Phylogeny, Protein Conformation, Time Factors.
Abstract
European brown hare syndrome virus (EBHSV) is the aetiological agent of European brown hare syndrome (EBHS), a disease affecting Lepus europaeus and Lepus timidus first diagnosed in Sweden in 1980. To characterize EBHSV evolution we studied hare samples collected in Sweden between 1982 and 2008. Our molecular clock dating is compatible with EBHSV emergence in the 1970s. Phylogenetic analysis revealed two lineages: Group A persisted until 1989 when it apparently suffered extinction; Group B emerged in the mid-1980s and contains the most recent strains. Antigenic differences exist between groups, with loss of reactivity of some MAbs over time, which are associated with amino acid substitutions in recognized epitopes. A role for immune selection is also supported by the presence of positively selected codons in exposed regions of the capsid. Hence, EBHSV evolution is characterized by replacement of Group A by Group B viruses, suggesting that the latter possess a selective advantage.
DOI: 10.1016/j.virol.2014.08.002
PubMed: 25155199
Affiliations:
- Australie, France, Italie, Portugal, Suède
- Nouvelle-Galles du Sud, Pays de la Loire, Région Bretagne
- Nantes, Rennes, Sydney
- Université de Nantes, Université de Sydney
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003301
- to stream PubMed, to step Curation: 003191
- to stream PubMed, to step Checkpoint: 003191
- to stream Ncbi, to step Merge: 001D41
- to stream Ncbi, to step Curation: 001D41
- to stream Ncbi, to step Checkpoint: 001D41
- to stream Main, to step Merge: 003733
- to stream Main, to step Curation: 003709
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).</title><author><name sortKey="Lopes, Ana M" sort="Lopes, Ana M" uniqKey="Lopes A" first="Ana M" last="Lopes">Ana M. Lopes</name><affiliation wicri:level="3"><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: analopes@cibio.up.pt.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Capucci, Lorenzo" sort="Capucci, Lorenzo" uniqKey="Capucci L" first="Lorenzo" last="Capucci">Lorenzo Capucci</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: lorenzo.capucci@izsler.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia</wicri:regionArea><wicri:noRegion>25124 Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Gavier Widen, Dolores" sort="Gavier Widen, Dolores" uniqKey="Gavier Widen D" first="Dolores" last="Gavier-Widén">Dolores Gavier-Widén</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Wildlife Disease, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden. Electronic address: dolores.gavier-widen@sva.se.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pathology and Wildlife Disease, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Le Gall Recule, Ghislaine" sort="Le Gall Recule, Ghislaine" uniqKey="Le Gall Recule G" first="Ghislaine" last="Le Gall-Reculé">Ghislaine Le Gall-Reculé</name><affiliation wicri:level="3"><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Avian and Rabbit Virology, Immunology, and Parasitology Unit, Ploufragan, France; European University of Brittany, Rennes, France. Electronic address: ghislaine.legall-recule@anses.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Anses, Ploufragan-Plouzané Laboratory, Avian and Rabbit Virology, Immunology, and Parasitology Unit, Ploufragan, France; European University of Brittany, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Brocchi, Emiliana" sort="Brocchi, Emiliana" uniqKey="Brocchi E" first="Emiliana" last="Brocchi">Emiliana Brocchi</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: emiliana.brocchi@izsler.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia</wicri:regionArea><wicri:noRegion>25124 Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Barbieri, Ilaria" sort="Barbieri, Ilaria" uniqKey="Barbieri I" first="Ilaria" last="Barbieri">Ilaria Barbieri</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: ilaria.barbieri@izsler.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia</wicri:regionArea><wicri:noRegion>25124 Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Quemener, Agnes" sort="Quemener, Agnes" uniqKey="Quemener A" first="Agnès" last="Quéméner">Agnès Quéméner</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: agnes.quemener@nantes.inserm.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Le Pendu, Jacques" sort="Le Pendu, Jacques" uniqKey="Le Pendu J" first="Jacques" last="Le Pendu">Jacques Le Pendu</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: jacques.le-pendu@univ-nantes.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Geoghegan, Jemma L" sort="Geoghegan, Jemma L" uniqKey="Geoghegan J" first="Jemma L" last="Geoghegan">Jemma L. Geoghegan</name><affiliation wicri:level="4"><nlm:affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: jemma.geoghegan@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name><affiliation wicri:level="4"><nlm:affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: edward.holmes@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Esteves, Pedro J" sort="Esteves, Pedro J" uniqKey="Esteves P" first="Pedro J" last="Esteves">Pedro J. Esteves</name><affiliation wicri:level="1"><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; CITS, Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, Gandra, Portugal. Electronic address: pjesteves@cibio.up.pt.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; CITS, Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, Gandra</wicri:regionArea><wicri:noRegion>Gandra</wicri:noRegion></affiliation></author><author><name sortKey="Abrantes, Joana" sort="Abrantes, Joana" uniqKey="Abrantes J" first="Joana" last="Abrantes">Joana Abrantes</name><affiliation wicri:level="1"><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal. Electronic address: jabrantes@cibio.up.pt.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão</wicri:regionArea><wicri:noRegion>Vairão</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25155199</idno><idno type="pmid">25155199</idno><idno type="doi">10.1016/j.virol.2014.08.002</idno><idno type="wicri:Area/PubMed/Corpus">003301</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003301</idno><idno type="wicri:Area/PubMed/Curation">003191</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003191</idno><idno type="wicri:Area/PubMed/Checkpoint">003191</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003191</idno><idno type="wicri:Area/Ncbi/Merge">001D41</idno><idno type="wicri:Area/Ncbi/Curation">001D41</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D41</idno><idno type="wicri:Area/Main/Merge">003733</idno><idno type="wicri:Area/Main/Curation">003709</idno><idno type="wicri:Area/Main/Exploration">003709</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).</title><author><name sortKey="Lopes, Ana M" sort="Lopes, Ana M" uniqKey="Lopes A" first="Ana M" last="Lopes">Ana M. Lopes</name><affiliation wicri:level="3"><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: analopes@cibio.up.pt.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Capucci, Lorenzo" sort="Capucci, Lorenzo" uniqKey="Capucci L" first="Lorenzo" last="Capucci">Lorenzo Capucci</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: lorenzo.capucci@izsler.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia</wicri:regionArea><wicri:noRegion>25124 Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Gavier Widen, Dolores" sort="Gavier Widen, Dolores" uniqKey="Gavier Widen D" first="Dolores" last="Gavier-Widén">Dolores Gavier-Widén</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Wildlife Disease, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden. Electronic address: dolores.gavier-widen@sva.se.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pathology and Wildlife Disease, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Le Gall Recule, Ghislaine" sort="Le Gall Recule, Ghislaine" uniqKey="Le Gall Recule G" first="Ghislaine" last="Le Gall-Reculé">Ghislaine Le Gall-Reculé</name><affiliation wicri:level="3"><nlm:affiliation>Anses, Ploufragan-Plouzané Laboratory, Avian and Rabbit Virology, Immunology, and Parasitology Unit, Ploufragan, France; European University of Brittany, Rennes, France. Electronic address: ghislaine.legall-recule@anses.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Anses, Ploufragan-Plouzané Laboratory, Avian and Rabbit Virology, Immunology, and Parasitology Unit, Ploufragan, France; European University of Brittany, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Brocchi, Emiliana" sort="Brocchi, Emiliana" uniqKey="Brocchi E" first="Emiliana" last="Brocchi">Emiliana Brocchi</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: emiliana.brocchi@izsler.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia</wicri:regionArea><wicri:noRegion>25124 Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Barbieri, Ilaria" sort="Barbieri, Ilaria" uniqKey="Barbieri I" first="Ilaria" last="Barbieri">Ilaria Barbieri</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy. Electronic address: ilaria.barbieri@izsler.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Zooprofilattico Sperimentale della Lombardia e dell׳Emilia Romagna, Via Bianchi 9, 25124 Brescia</wicri:regionArea><wicri:noRegion>25124 Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Quemener, Agnes" sort="Quemener, Agnes" uniqKey="Quemener A" first="Agnès" last="Quéméner">Agnès Quéméner</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: agnes.quemener@nantes.inserm.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Le Pendu, Jacques" sort="Le Pendu, Jacques" uniqKey="Le Pendu J" first="Jacques" last="Le Pendu">Jacques Le Pendu</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes, France. Electronic address: jacques.le-pendu@univ-nantes.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR892, CNRS, UMR6299, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Geoghegan, Jemma L" sort="Geoghegan, Jemma L" uniqKey="Geoghegan J" first="Jemma L" last="Geoghegan">Jemma L. Geoghegan</name><affiliation wicri:level="4"><nlm:affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: jemma.geoghegan@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name><affiliation wicri:level="4"><nlm:affiliation>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: edward.holmes@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Emerging Infectious and Biosecurity Institute, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Esteves, Pedro J" sort="Esteves, Pedro J" uniqKey="Esteves P" first="Pedro J" last="Esteves">Pedro J. Esteves</name><affiliation wicri:level="1"><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; CITS, Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, Gandra, Portugal. Electronic address: pjesteves@cibio.up.pt.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal; CITS, Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, Gandra</wicri:regionArea><wicri:noRegion>Gandra</wicri:noRegion></affiliation></author><author><name sortKey="Abrantes, Joana" sort="Abrantes, Joana" uniqKey="Abrantes J" first="Joana" last="Abrantes">Joana Abrantes</name><affiliation wicri:level="1"><nlm:affiliation>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão, Portugal. Electronic address: jabrantes@cibio.up.pt.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>CIBIO-UP, Centro de Investigação em Biodiversidade e Recursos Genéticos-Universidade do Porto/InBIO, Laboratório Associado, Vairão</wicri:regionArea><wicri:noRegion>Vairão</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology</title><idno type="eISSN">1096-0341</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term><term>Antigens, Viral (genetics)</term><term>Antigens, Viral (metabolism)</term><term>Bunyaviridae Infections (epidemiology)</term><term>Bunyaviridae Infections (veterinary)</term><term>Bunyaviridae Infections (virology)</term><term>Epitopes (genetics)</term><term>Evolution, Molecular</term><term>Gene Expression Regulation, Viral (physiology)</term><term>Genetic Variation</term><term>Hares (virology)</term><term>Lagovirus (genetics)</term><term>Liver (virology)</term><term>Models, Molecular</term><term>Phylogeny</term><term>Protein Conformation</term><term>Sweden (epidemiology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term><term>Antigènes viraux (génétique)</term><term>Antigènes viraux (métabolisme)</term><term>Conformation des protéines</term><term>Facteurs temps</term><term>Foie (virologie)</term><term>Infections à Bunyaviridae (médecine vétérinaire)</term><term>Infections à Bunyaviridae (virologie)</term><term>Infections à Bunyaviridae (épidémiologie)</term><term>Lagovirus (génétique)</term><term>Lepus (virologie)</term><term>Modèles moléculaires</term><term>Phylogénie</term><term>Régulation de l'expression des gènes viraux (physiologie)</term><term>Suède (épidémiologie)</term><term>Variation génétique</term><term>Épitopes (génétique)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Sweden</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Bunyaviridae Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lagovirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes viraux</term><term>Lagovirus</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Bunyaviridae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Régulation de l'expression des gènes viraux</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation, Viral</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Bunyaviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Foie</term><term>Infections à Bunyaviridae</term><term>Lepus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bunyaviridae Infections</term><term>Hares</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à Bunyaviridae</term><term>Suède</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Evolution, Molecular</term><term>Genetic Variation</term><term>Models, Molecular</term><term>Phylogeny</term><term>Protein Conformation</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term><term>Conformation des protéines</term><term>Facteurs temps</term><term>Modèles moléculaires</term><term>Phylogénie</term><term>Variation génétique</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suède</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">European brown hare syndrome virus (EBHSV) is the aetiological agent of European brown hare syndrome (EBHS), a disease affecting Lepus europaeus and Lepus timidus first diagnosed in Sweden in 1980. To characterize EBHSV evolution we studied hare samples collected in Sweden between 1982 and 2008. Our molecular clock dating is compatible with EBHSV emergence in the 1970s. Phylogenetic analysis revealed two lineages: Group A persisted until 1989 when it apparently suffered extinction; Group B emerged in the mid-1980s and contains the most recent strains. Antigenic differences exist between groups, with loss of reactivity of some MAbs over time, which are associated with amino acid substitutions in recognized epitopes. A role for immune selection is also supported by the presence of positively selected codons in exposed regions of the capsid. Hence, EBHSV evolution is characterized by replacement of Group A by Group B viruses, suggesting that the latter possess a selective advantage.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>Portugal</li><li>Suède</li></country><region><li>Nouvelle-Galles du Sud</li><li>Pays de la Loire</li><li>Région Bretagne</li></region><settlement><li>Nantes</li><li>Rennes</li><li>Sydney</li></settlement><orgName><li>Université de Nantes</li><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Lopes, Ana M" sort="Lopes, Ana M" uniqKey="Lopes A" first="Ana M" last="Lopes">Ana M. Lopes</name></region><name sortKey="Le Gall Recule, Ghislaine" sort="Le Gall Recule, Ghislaine" uniqKey="Le Gall Recule G" first="Ghislaine" last="Le Gall-Reculé">Ghislaine Le Gall-Reculé</name><name sortKey="Le Pendu, Jacques" sort="Le Pendu, Jacques" uniqKey="Le Pendu J" first="Jacques" last="Le Pendu">Jacques Le Pendu</name><name sortKey="Quemener, Agnes" sort="Quemener, Agnes" uniqKey="Quemener A" first="Agnès" last="Quéméner">Agnès Quéméner</name></country><country name="Italie"><noRegion><name sortKey="Capucci, Lorenzo" sort="Capucci, Lorenzo" uniqKey="Capucci L" first="Lorenzo" last="Capucci">Lorenzo Capucci</name></noRegion><name sortKey="Barbieri, Ilaria" sort="Barbieri, Ilaria" uniqKey="Barbieri I" first="Ilaria" last="Barbieri">Ilaria Barbieri</name><name sortKey="Brocchi, Emiliana" sort="Brocchi, Emiliana" uniqKey="Brocchi E" first="Emiliana" last="Brocchi">Emiliana Brocchi</name></country><country name="Suède"><noRegion><name sortKey="Gavier Widen, Dolores" sort="Gavier Widen, Dolores" uniqKey="Gavier Widen D" first="Dolores" last="Gavier-Widén">Dolores Gavier-Widén</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Geoghegan, Jemma L" sort="Geoghegan, Jemma L" uniqKey="Geoghegan J" first="Jemma L" last="Geoghegan">Jemma L. Geoghegan</name></region><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name></country><country name="Portugal"><noRegion><name sortKey="Esteves, Pedro J" sort="Esteves, Pedro J" uniqKey="Esteves P" first="Pedro J" last="Esteves">Pedro J. Esteves</name></noRegion><name sortKey="Abrantes, Joana" sort="Abrantes, Joana" uniqKey="Abrantes J" first="Joana" last="Abrantes">Joana Abrantes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003709 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003709 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25155199
|texte= Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV).
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25155199" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |